The initiative for Fostering DIHs for Embedding Interoperability in Cyber-Physical Systems of European SMEs (DIH4CPS) will help European enterprises overcome the innovation hurdles and establish Europe as a world leading innovator of the Fourth Industrial Revolution. DIH4CPS will create an embracing, interdisciplinary network of DIHs and solution providers, focussed on cyber-physical and embedded systems, interweaving knowledge and technologies from different domains, and connecting regional clusters with the pan-European expert pool of DIHs.